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Meeting 2023 TMS Annual Meeting & Exhibition
Symposium Biological Materials Science
Presentation Title Probing Function and Degeneration in Elastic Biopolymers
Author(s) Anna Tarakanova
On-Site Speaker (Planned) Anna Tarakanova
Abstract Scope Elastic biopolymers sustain critical mechanical and biochemical functions in human elastic tissues. Mature elastic fibers are exceptionally resistant to mechanical and physicochemical stress under healthy conditions, retaining their biomechanical function over the human lifespan. However, due to their longevity, during biological aging and in most prominent chronic diseases, including diabetes mellitus, cardiovascular disease, and osteoarthritis, elastic tissues experience progressive mechanical degeneration. Over time, deleterious modifications to elastin—the key structural protein in elastic tissues that imparts elasticity and recoil function to skin, lungs, and arteries—accumulate, leading to severe symptoms in cardiovascular, pulmonary, and skeletal connective tissues. Deconvoluting multifactorial triggers that drive compromised tissue elasticity remains a challenge at the nanoscale as physicochemical stressors are concurrent and interlinked. We present recent work to probe the chemical complexity of elastic fiber assembly, function and degeneration in aging and disease through a multiscale in silico framework.
Proceedings Inclusion? Planned:
Keywords Modeling and Simulation, Biomaterials, Mechanical Properties

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

3D Printed Stimuli-responsive Hydrogels for Drug Delivery
A Concise Review of the Antibacterial Action of Gold Nanoparticles Against Various Bacteria
A Novel Glass-based Material for Vital Pulp Therapy: Biocompatibility and Physiochemical Properties
A Review of Nanovanadium Compounds for Cancer Cell Therapy
Antibacterial Activity of Chitosan-based Spiky Gold Nanoparticles-hydrogel
Bio-inspired 3-phase Composites for Improved Impact Resistance
Bio-Inspired Composites and Metamaterials from High-aspect Ratio Ribbons
Bioactive Tissue Derived Nanocomposite Gel for Permanent Arterial Embolization
Biodegradation of Petroleum-based Plastic Using Bacillus sp.
Biofilms as Active Materials
Bioinspired Materials Inspired by Biological Structural Design Elements
Biological Designs that Prevent Catastrophic Damage
Biomineralized Architected Microlattice in Starfish Ossicles: Structure, Mechanics, Morphogenesis, and Bio-Inspired Design
Effect of Calcium Phosphorous Molar Ratio on Biocompatibility of 316L Stainless Steel
Effect of Collagen Molecular Damage at the Nanoscale on Different Hierarchical Levels
Exploring the Mechanics of Force Transduction in the Tooth-stylus-radula System of Chitons
Finite Element Analyses of Cracks in Lateral Incisors under Quantitative Percussion Conditions
Fungi-inspired Absorption Materials Made Using Different Biotemplating Methods
Graphene Foam as an Active Bioscaffold for Cartilage Tissue Engineering
Hierarchical, Progressive Collapsibility in the Impact Resistant Jackfruit
Investigation of Design Principles from the Cholla Cactus using Finite Element Simulations and In situ Mechanical Testing
K-10: Revealing Toughening Mechanisms in Coconut Endocarp
K-5: A Systematic, Phylogeny-based Study of the Structural, Crystallographic, and Mechanical Properties of Avian Eggshells
K-6: Bioinspired Magnetic Freeze Casting with Particles of Differing Shapes
K-7: Complex Variable Method to Analyze Bio-inspired Phononic Metamaterials
K-8: Effect of Substrate Density on Structure and Physiology of Fungal Hyphal Systems
K-9: On the Mechanical Properties of Dual-scale Microlattice of Starfish Ossicles: A Computational Study
Mechanical Behavior and Response of the Horse Hoof Wall's Internal Architecture using In-situ MicroCT
Mechanical Properties of Stretchable, Mechanochemically Active Hydrogels
Mechanics of Bioinspired Hierarchical Tape-springs
Micro X-ray Computed Tomography Study of Moisture-induced Swelling in the Wood Cellular Structure
Micromechanical Investigations of the Remarkable Damage Tolerance in Tooth-enamel of Hadrosaurid Dinosaurs
Multi-scale Biomechanical Analysis of Fungal Sporocarps and Their Constitutive Components
Notched 3D Printed Replica Teeth for In Vitro Characterization of Dental Cracks with Quantitative Percussion Diagnostics
Novel Zn-Cu-Al-TiC Nanocomposites for Biodegradable Stent Application
Porous, Freeze-cast Fluorohydroxyapatite and Hydroxyapatite-titania Composites for Biomedical Applications
Prestressing Bioceramics: On the Structural Origins and Mechanical Significance of Residual Stresses in Sea Urchin Spines
Probing Dynamic Structure-function Relationship of Bone at the Nanoscale
Probing Function and Degeneration in Elastic Biopolymers
Protecto-flexible Bioinspired Design
Real-time Investigations of Tensile and Fracture Behavior of Fibers from the Venus Flower Basket (Euplectella Aspergillum)
Reinforced Freeze-cast Ceramics Using Uniform Magnetic Fields
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Reusable Hydrogel Drug Delivery Devices and Their Release Kinetics
Sclerites from the Gorgonian Octocoral, Lophogorgia Chilensis: A Biological Mechanotunable System Based on Granular Jamming
Sensitivity Analysis of Bio-inspired Phononic Materials Using the Hypercomplex Taylor Series Expansion Method
Structure-mechanics-performance of Fish-fins as Inspiration for Robotic Materials
The Mechanics of Living Organisms: Some Observations
Ultrasonic Characterization of Wave Propagation in Biomineralized Materials
Understanding the Fibrous Nodal Design at the Sieve Plate of Glass Sponge E. aspergillum: A Structural-mechanical Exploration
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