| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Investigation of Cellular Attachment and Morphology on a 3D-printed Curved Micropillar Substrate |
| Author(s) |
Eduardo Pena, Md Shahriar, Changxue Xu |
| On-Site Speaker (Planned) |
Eduardo Pena |
| Abstract Scope |
Cells in the complex extracellular matrix are arranged in a three-dimensional configuration. Curving and folding of tissues are common architectural phenotypes that provide the unique advantage of enhanced surface area, cell viability, and cellular functionality. Most of the cell culture and tissue engineering studies involve 2D planar surfaces which do not represent the realistic complexity of the cellular microenvironment. Therefore, it is of great importance to develop 3D architectures including curvature featuring biocompatible materials that provide necessary physio-mechanical and chemical properties for cellular proliferation and differentiation. Recently, the two-photon polymerization technique has gained more and more attention as a high-precision 3D printing technology for various biomedical and tissue engineering applications. In this study, flat and curved micropillar substrates have been fabricated using the two-photon polymerization technique. The main objective of this research is to investigate the effect of the substrate shape (curved vs flat) on the cellular attachment and morphology. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |