A high-throughput experimental method is developed to study the high entropy alloys (HEAs) based on the powder metallurgy sintering approach. The high-throughput Hot-Isostatic Pressing (HIP) micro-synthesis method utilize elemental powders, laser-based additive manufacturing, HIP and heat treatment processes to form more than 80 bulk HEAs with various chemistry. These combinatorial HEAs contain 13 elements, including Fe, Cr, Co, Ni, Mo, Mn, W, Si, Nb, Ti, Ta, Cu, and Al. There are 18 types of material system among these HEAs. They are characterized by different high-throughput analyzing methods, such as LIBS, micro-XRF, Full-View-Metallography, SEM, micro-XRD and Scanning-Micro-Hardness etc. The effects of chemistry on microstructure and property are studied via experiments and theoretical modeling. This work put forth a new high-throughput HIP micro-synthesis approach for accelerating the design and screening of bulk HEAs and other materials.