Wearable electronic devices that can noninvasively and continuously acquire vital signs from the human body represent an important trend for healthcare. Combined strategies of materials design and advanced microfabrication allow the integration of various components and devices on a wearable platform, resulting in functional systems with minimal constraints on the human body. Physiological signals in deep tissues are particularly valuable, because they have a stronger and faster correlation with the events in the human body than those signals on the skin surface. In this presentation, I will demonstrate a soft ultrasonic technology that can noninvasively and continuously acquire dynamic information about our deep tissues and central organs. I will demonstrate use cases of this soft ultrasonic technology in recording blood pressure and flow waveforms in central vessels, cardiac chamber activities, and core body temperatures. The soft ultrasonic technology represents a platform that holds profound implications for a wide range of applications in consumer electronics, sports medicine, defense, and clinical practices.