|About this Abstract
||2023 TMS Annual Meeting & Exhibition
||Functional Nanomaterials 2023
||Magnetic Robot with Localized Flexibility (MR-LF)
||Taylor E. Greenwood, Henry Cagle, Benson Pulver, On Shun Pak, Yong Lin Kong
|On-Site Speaker (Planned)
||Taylor E. Greenwood
The gastrointestinal (GI) tract is a highly constrained and complex luminal construct that fundamentally limits the size of an ingestible system. Recent advancements in mesoscale magnetic crawlers have demonstrated the ability to effectively traverse complex and confined systems by leveraging magnetic fields to induce contraction and bending-based locomotion. However, the integration of functional components (e.g., electronics) in the proposed ingestible system remains fundamentally challenging. Herein, the creation of a centralized compartment in a magnetic robot by imparting localized flexibility (MR-LF) is demonstrated. The centralized compartment enables MR-LF to be readily integrated with modular functional components and payloads, such as commercial off-the-shelf electronics and medication, while preserving its bidirectionality in an ingestible form factor. The ability of MR-LF to incorporate electronics, perform drug delivery, guide continuum devices such as catheters, and navigate air–water environments in confined lumens is demonstrated. The MR-LF enables functional integration to create a highly integrated ingestible system that can ultimately address a broad range of unmet clinical needs.