Emerging 2D semiconductors (such as transition metal dichalcogenides (TMDCs) and black phosphorus), along with their heterostructures (particularly with graphene and hexagonal boron nitride (h-BN) layers), offer compelling platforms for creating new nanoelectromechanical systems (NEMS) for multiphysical transducers, where the unconventional properties of these crystals are harnessed for engineering both classical and quantum signal processing and sensing schemes. In this presentation, I will describe some of my group’s latest endeavors on advancing resonant NEMS with 2D materials and van der Waals heterostructures. After reviewing important fundamentals of 2D NEMS, I will demonstrate examples of how the special properties of these 2D structures have led to new device functions and performance beyond conventional NEMS. Toward quantum engineering, atomistic defects in ultrawide-bandgap h-BN crystal support intriguing quantum emitters (QEs). Leveraging our experience in SiC and 2D devices, we explore these platforms and their hybrid integration, toward developing quantum transduction functions in chip-scale systems.