| About this Abstract |
| Meeting |
Materials Science & Technology 2020
|
| Symposium
|
Synthesis, Characterization, Modeling and Applications of Functional Porous Materials
|
| Presentation Title |
Development of Nanostructured Vycor Glass Microspheres for Doxorubicin Administration |
| Author(s) |
Bryan Escalante Castro, Yanina Martinez, Guillermo Zampieri, Yrina Viatela |
| On-Site Speaker (Planned) |
Bryan Escalante Castro |
| Abstract Scope |
In the present work, nanostructured porous SiO2 microspheres were developed for future drug release applications of doxorubicin. The glass has a nominal composition of 65.6SiO2 ·27.8 B 2 O 3 ·6.0Na 2 O·0.6Al 2 O 3 weight percent. Microspheres with a regular morphology and 25-35µm size were made by flame spheroidization method. The porous microspheres were obtained by a thermal separation treatment at 660°C for 6 and 10 hours so two immiscible phases were obtained one is rich in silica and the other one is rich in boron and sodium. After the lixiviation for 2 and 4 days, SEM images showed a greater interconnectivity of the pores as the phase separation time increased. The composition is mostly SiO2 studied by EDS and XPS Spectrofluorimetry of intensity vs concentration of doxorubicin showed a LogNormal distribution in deionized water. These results are important to relate release studies and pi-stacking of the drug. |