About this Abstract |
Meeting |
MS&T23: Materials Science & Technology
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Symposium
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Interface-mediated Phenomena in Structural Materials
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Presentation Title |
Nanoscale Hydration at the Collagen-mineral Interface’s Role in Overall Tissue Strength of Human Cortical Bone |
Author(s) |
Elizabeth Montagnino, Samantha Ferengul, Thomas Siegmund , John Howarter |
On-Site Speaker (Planned) |
Elizabeth Montagnino |
Abstract Scope |
Bone is a hierarchal composite material, composed of type I collagen, carbonated apatite, and water, which can either be mobile or bound within the nanoscale foundation. Water at the nanoscale collagen-mineral interface enhances the load transfer between the phases. Small-angle X-ray scattering (SAXS) and wide-angle X-ray scattering (WAXS) was used to characterize native and demineralized, human cortical bone specimens, investigated under controlled degrees of hydration and pharmaceutical intervention. Experiments are designed to understand the effects of hydration on the collagen-mineral interface via the degree of swelling of the collagen triple helix and phase changes in the apatite. We pair the experiments with finite element simulations of the residual stress states in the mineralized collagen fibril. We demonstrate that interface strength, together with residual stress states formed from swelling and phase transformation affect the deformation response of cortical bone. This work is supported by NSF Award 1952993 |