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Meeting 2022 TMS Annual Meeting & Exhibition
Symposium Nix Award and Lecture Symposium: Nanomechanics and Mechanomaterials
Presentation Title Modeling Programmable Drug Delivery in Bioelectronics with Electrochemical Actuation
Author(s) Yonggang Huang
On-Site Speaker (Planned) Yonggang Huang
Abstract Scope Drug delivery systems featuring electrochemical actuation represent an emerging class of biomedical technology with programmable volume/flowrate capabilities for localized delivery. For programmable delivery, the available flowrate control and delivery time models fail to consider key variables of the drug delivery system––microfluidic resistance and membrane stiffness. Here we establish an analytical model that accounts for the missing variables and provides a scalable understanding of each variable influence in the physics of delivery process (i.e., maximum flowrate, delivery time). This analytical model accounts for the key parameters––initial environmental pressure, initial volume, microfluidic resistance, flexible membrane, current, and temperature––to control the delivery and bypasses numerical simulations allowing faster system optimization for different in vivo experiments. We show that the delivery process is controlled by three nondimensional parameters, and the volume/flowrate results from the proposed analytical model agree with the numerical results and experiments.
Proceedings Inclusion? Planned: None Selected


2022 William D Nix Award Lecture: Mechano-materials: Engineering Mechanical Properties of Materials with Internal Interfaces and Lightweight Structures
Materials by Design: Three-dimensional (3D) Nano-architected Meta-materials
Modeling Programmable Drug Delivery in Bioelectronics with Electrochemical Actuation
Release with Ease – Bioinspired Designs for Placing Micro-objects

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