|About this Abstract
||2022 TMS Annual Meeting & Exhibition
||The Comparability of In Vitro and In Vivo Experiments for Degradable Mg-implants
||Regine Willumeit Romer, Stefan Bruns, Heike Helmholz, Norbert Hort, Diana Krueger, Yu Sun, Bjoern Wiese, Berit Zeller-Plumhoff
|On-Site Speaker (Planned)
||Regine Willumeit Romer
Mg implants pose a great potential for clinical applications. Thousands of patients are already successfully treated with Mg implants, and more products get approval. Despite the fact that it works we know that we have not yet reached full understanding of all processes which occur during the degradation of the material and tissue regeneration. We might perhaps never come to a complete description of the physical, chemical and biological processes during healing. And perhaps it is not necessary to fully unravel all details of the reactions and interactions. We already can conclude that in vitro experiments can predict many observations found in vivo with a sufficient precision. This presentation will give an overview of what we know for in vitro, in vivo degradation as well as in vivo imaging (synchrotron radiation tomography), and histology, their limitations and how to overcome them.
||Biomaterials, Characterization, Magnesium