Development and maturation of the physics based models in general, and ICME / CM frameworks in particular have been steadily expanding across the industry. However, their use in qualification and especially certification processes at present remains very limited. Some of the contributing factors include relatively low TRL levels for these technologies, and limited engagement with the certifying agencies. This presentation briefly discusses both challenges and enablers for the broader use of ICME / CM in the qualification and certification domains for new materials and processes. Several examples will be used to illustrate these concepts, highlighting both successful application experience, as well as the areas where the use of ICME / CM methods could result in substantial improvements over the current state. The above topics will be presented from the regulator’s perspective.