Using the calculation of phase diagrams method (CALPHAD) coupled with high-throughput computation (HTC) is efficient for developing high-entropy alloys. Pandat software with the PanHEA database was used for simulations. First, 17 points of the Al-Co-Fe-Ni-Ti alloy system, which may form a high-entropy alloy, were calculated, and six alloys, such as Al11Co26Fe28Ni29Ti6, Al6Co31Fe33Ni24Ti6, Al11Co11Fe33Ni34Ti11, Al6Co31Fe23Ni34Ti6, Al11Co31Fe18Ni34Ti6 and Al11Co31Fe33Ni19Ti6, were selected for experiments. It is hoped that high-entropy alloys mainly composed of a face-centered-cubic FCC structure. The alloys were prepared by an arc melting furnace, followed by the heat treatment at 1,000°C for 72 hours. The experimental results indicated that the six alloys mainly consisted of FCC phases. However, some other structures, such as FCC_L12, B2_BCC and H_L21 structures, were also formed. In this study, the solidification and stable phase of high-entropy alloys were successfully calculated by Pandat software with HTC, which can save the alloy design time and material cost.