About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Novel Decellularized, Dehydrated Human Placental Extracellular Matrix (ECM) Mineral Composite for Bone Applications |
| Author(s) |
Rajarajeswari Sivalenka, Brandon Mirabile, Robert Pouliot, Maumita Bhattacharjee, Joseph Gleason, Nicolas Mann, Lukasz Przek, Desiree Long, Adrian Kilcoyne, Robert J. Hariri, Stephen A. Brigido, Anna Gosiewska |
| On-Site Speaker (Planned) |
Rajarajeswari Sivalenka |
| Abstract Scope |
A novel decellularized human placental extracellular matrix (ECM) mineral composite has been developed for bone void applications. Celularity’s proprietary processing steps for decellularization included complete removal of cells, nucleic acids, and bioactive factors, in alignment with 510(k) medical device requirements. The final product, formulated using decellularized ECM with mineral, β-TCP, is designed as a biocompatible, osteoconductive bone void filler. The ECM porosity and ratio of ECM to β-TCP were optimized to meet clinical needs. The product functions as a resorbable, osteoconductive bone void filler to fill bony defects in the skeletal system, as demonstrated in preclinical models using critical size femur defects in rabbits. Following placement in bony void or gap, the product is replaced by bone regrowth during the healing process. Our findings indicate a promising application of the placental ECM/ β-TCP composite for filling bony voids or gaps of the skeletal system, the extremities, spine, and pelvis. |