About this Abstract |
| Meeting |
MS&T26: Materials Science & Technology
|
| Symposium
|
Controlled Synthesis, Processing, and Applications of Structural and Functional Nanomaterials
|
| Presentation Title |
Luminescent Hydroxyapatite Scaffolds for Osteogenic Differentiation and Bone Remodeling |
| Author(s) |
Olivia A. Graeve, Lidia F. Vazquez, Fabian Martinez Pallares, Elena Sofia Cardenas Alcoser, J. Silvio Gutkind |
| On-Site Speaker (Planned) |
Olivia A. Graeve |
| Abstract Scope |
Calcium phosphate ceramics, particularly hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP), are extensively utilized in bone regeneration due to their chemical and structural similarity to native bone mineral. In this study, we investigate europium-doped hydroxyapatite (HAp:Eu) scaffolds fabricated by unidirectional freeze casting. HAp:Eu powders were synthesized and thermally processed to modulate phase composition, including controlled β-TCP formation, and particle size. Three-dimensional scaffolds were fabricated using unidirectional freeze casting to generate anisotropic, aligned porosity that models key architectural features of bone. The scaffolds were employed as a three-dimensional matrix for osteoblast and osteoclast co-culture to capture key aspects of coupled bone remodeling, including matrix deposition and resorption. Cytocompatibility was assessed via LDH release and cell viability assays, confirming minimal cytotoxicity and sustained viability. Together, these results suggest that HAp:Eu scaffolds are promising luminescent platforms for future studies of bone marrow stem cells response, osteogenic differentiation, and bone remodeling. |