About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry
|
| Presentation Title |
Nanorobotics for Early Detection and Targeted Treatment of Pancreatic Ductal Adenocarcinoma |
| Author(s) |
Kate Fox, Shawn Goussous, Melissa Stanfield, William Louis, Nhiem Tran |
| On-Site Speaker (Planned) |
Kate Fox |
| Abstract Scope |
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with 70% of patients surviving less than one year and 90% surviving less than five years post-diagnosis. Its poor prognosis is largely attributed to late detection and resistance to conventional therapies, driven by the tumour’s dense fibrotic stroma and poor vascularisation that severely limit drug penetration.
We present a novel nanorobotic platform designed to overcome the hostile PDAC microenvironment. Engineered for targeted navigation, extracellular matrix penetration, and stimuli-responsive release, our nanocarriers deliver therapeutics deep into tumour tissues, including poorly perfused regions inaccessible to standard treatments. This approach transforms a major biological barrier into an opportunity for highly precise therapeutic delivery. Our technology employs nanorobotics to seek out, bind to, and flag cancer cells using an injected encapsulated shell with real-time read-out capabilities. The platform enables earlier diagnosis, offering the potential to significantly improve survival rates and quality of life. |