About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
|
| Presentation Title |
Angiogenic Potential of Mesoporous Bioactive Glass in Medical Applications |
| Author(s) |
Martin Michalek, Martina Vitazkova, Zulema Vargas, Andrea Soltysova, Dusan Galusek |
| On-Site Speaker (Planned) |
Martin Michalek |
| Abstract Scope |
Bioactive glass with 45S5 compositions prepared by conventional melting and co-doped by B and Co has enhanced angiogenesis via increased vascular endothelial growth factor (VEGF) expression. In the current study, mesoporous bioactive glass (MBGs) was produced and co-doped with the B and Co therapeutic ions by a sol-gel method. The MBGs morphology, cell viability and bioactivity were studied by SEM, XRD, BET, and in vitro bioactivity testing. The VEGF expression improved significantly compared to the melt-quenched glass doped with the same therapeutic ions. The influence on angiogenesis was further tested on selected genes, directly participating in angiogenesis processes, e.g. ILs, NOS, FGF, TGF and COL18A1. Their expression was analyzed via RT-PCR, western blot and ELISA. The material's potential in the medical sector was targeted for theragnostic composites by incorporating superparamagnetic iron oxide particles (SPIONs). This was done for diagnostic and therapeutic applications requiring magnetism and angiogenesis. |