About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
On the Effect of Type 2 Diabetes on Bone's Mechanical Properties |
| Author(s) |
Juan Pablo Viaux, William Woolley, Claire Acevedo |
| On-Site Speaker (Planned) |
Juan Pablo Viaux |
| Abstract Scope |
Type 2 diabetes (T2D) is a growing global health concern, known to adversely affect multiple physiological systems, including skeletal integrity. Among its systemic effects, increased fracture risk is well documented, yet the mechanical behavior of diabetic bone under hydrated physiological conditions remains incompletely characterized. This study investigates the impact of T2D on bone mechanics using an in vitro glycation protocol to simulate diabetic conditions in bovine cortical bone. Ribosylated and control samples were subjected to comprehensive mechanical testing at 37°C and constant hydration, including uniaxial strength, fracture toughness, and fatigue life under cyclic loading. Our findings reveal that glycation compromises all evaluated mechanical properties of bone. These results underscore the importance of accounting for diabetic-specific degradation in skeletal assessments and may inform future models and therapies aimed at mitigating fracture risk in diabetic patients |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Other |