| Abstract Scope |
3D Printing (3DP) or additive manufacturing (AM) technology can produce patient-matched implants for special anatomical needs or concerns related to specific defect size complexity. However, establishing process property relationships for different AM techniques is vital to successfully implementing these manufacturing practices in biomedical devices. Calcium phosphate (CaP) ceramics, compositionally similar to the inorganic part of bone, show significant promise for implant applications in 3DP scaffolds and surface-modified hip and knee implants. Chemistry plays a vital role in controlling their mechanical strength and biological properties. Natural medicinal compounds (NMCs) loading on 3DP CaP scaffolds and coatings on Titanium show improved osteogenesis, angiogenesis, and controlled drug delivery, using in vivo studies. Polymer encapsulation and metal ion complexation of these NMCs support bioavailability and release kinetics, showing antibacterial properties and reducing osteosarcoma cell proliferation. These systems show promise for their use in orthopedic and dental devices while improving the current hip/knee implant lifetime. |