About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Design of Antibacterial Neural Interface Electrodes Using Hierarchical Surface Restructuring and Metal Oxide Thin Films |
| Author(s) |
Henna Khosla, Wesley Seche, Kriti Panchal, Steve May, Ekaterina Pomerantseva, Jacob Elmer, Jeffrey Hettinger, Gregory Caputo, Shahram Amini, Gang Feng |
| On-Site Speaker (Planned) |
Gang Feng |
| Abstract Scope |
Next-generation implantable neural interfaces require miniaturized electrodes that maintain high electrochemical performance, long-term biocompatibility, and resistance to infection. Femtosecond laser–based Hierarchical Surface Restructuring (HSR™) increases electrochemically active surface area, improving charge storage capacity and reducing impedance; however, implant-associated infections remain a major clinical challenge, especially amid rising antibiotic resistance. This proposal develops multifunctional antibacterial neural electrodes by combining HSR™ with plasma-enhanced atomic layer deposition (PEALD). Ultrathin conformal copper oxide and zinc oxide coatings are deposited on hierarchically restructured platinum-iridium and titanium electrodes to provide intrinsic antibacterial activity while preserving electrochemical benefits. ZnO films produced by oxygen and oxygen-hydrogen PEALD, including ZnO-Zn nanocomposites, and CuO coatings are characterized for morphology, composition, and structure. Antibacterial efficacy against Escherichia coli and Staphylococcus aureus is evaluated alongside electrochemical performance. This work aims to establish a scalable platform for infection-resistant, high-performance neural electrodes for long-term implantation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Surface Modification and Coatings, Nanotechnology |