About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Fracture and Deformation Across Length Scales: Celebrating the Legacy of William Gerberich
|
| Presentation Title |
Modulus as a Comminution Compass: Linking Nanoindentation Stiffness to Jet-Milling Size Reduction |
| Author(s) |
Soumyadeep Sen, Tianyi Xiang, Zijian Wang, Tianxiang Gao, Najma Jamac, Calvin Sun, Nathan A. Mara |
| On-Site Speaker (Planned) |
Soumyadeep Sen |
| Abstract Scope |
Comminution is often optimized empirically through cumbersome bulk tests that demand high time and material consumption, even though fragmentation is governed by deformation and fracture processes that initiate at small length scales. Here we show that the reduced modulus (Er) measured by single-crystal nanoindentation enables bulk-scale jet-milling size-reduction prediction for pharmaceutical molecular crystals under fixed processing conditions. Motivated by contact mechanics, indentation-derived stiffness is used as a proxy for elastic energy storage and stress transmission during high-rate particle impacts, which controls the competition between crack formation and plastic accommodation. Across chemically distinct crystals with different packing and slip–fracture tendencies, Er exhibits a strong monotonic relationship with percent size reduction metrics . Simple modulus-based models achieved low cross-validated error within the calibrated stiffness window both for training dataset as well as independent literature datasets, providing a compact structure–property–performance bridge from nanoscale single-crystal mechanics to industrial comminution outcomes. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Mechanical Properties, Composites, Characterization |