| About this Abstract | 
   
    | Meeting | 2026 TMS Annual Meeting & Exhibition | 
   
    | Symposium | Biological Materials Science | 
   
    | Presentation Title | Mechanical characterization of Col1a1+/- osteogenesis imperfecta type I bone | 
   
    | Author(s) | Hanwen  Fan, Yuxiao  Zhou | 
   
    | On-Site Speaker (Planned) | Hanwen  Fan | 
   
    | Abstract Scope | Osteogenesis imperfecta (OI) is a genetic disorder caused by mutations in type I collagen that leads to fragile bones. However, the correlation between genetic mutation and bone fragility at macro-scale is not well understood. This study examined how pathological alterations in microstructure and composition in OI bones impair bone mechanical strength. | 
   
    | Proceedings Inclusion? | Planned: |