| Abstract Scope |
gnetic hyperthermia, which uses superparamagnetic nanoparticles, is a promising method for non-invasive, localized cancer treatment. To enhance this method's effectiveness, various surface modifications, such as single or successive coatings, can be applied to the nanoparticles to add multifunctionality. Understanding how the properties and morphology of the magnetic core and surface coatings affect heating performance is crucial for clinical applications. In this study, Fe3O4 superparamagnetic nanoparticles were synthesized and coated with oleic acid, silica, and surface amination. These materials were characterized using FTIR, XRD, TEM/EDS microscopy, and VSM measurements. Experimental studies assessed the heating performance of the nanoparticles using nanoparticle/agarose gel composite samples, with temperature changes on the top surface monitored under an externally applied magnetic field. Additionally, finite element transient thermal analyses simulated the heating behavior to understand the effects of various parameters on nanoparticle heating performance.
Keywords: Magnetic hyperthermia, superparamagnetic nanoparticles, surface modification, finite element analysis. |