About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Magnesium Technology 2026
|
| Presentation Title |
Evaluation of LZ21 for bioabsorbable pediatric vascular applications |
| Author(s) |
Jesse Gerringer , Adam Griebel , Roger J. Guillory |
| On-Site Speaker (Planned) |
Roger J. Guillory |
| Abstract Scope |
Development of magnesium (Mg) materials for bioabsorbable medical devices has advanced significantly within the last 20 years. Engineered Mg biomaterials should combine satisfactory ductility, strength, bioabsorbtion profile, and biocompatibility in challenging applications. In this project, a novel Mg alloy (LZ21) is evaluated for pediatric vascular applications. A well-established adult (250g, >12 weeks old) rodent surgical vascular wire implant model was adapted for neonate / juvenile (20g-60g, 2-4 weeks old) rat implantation. Wires of LZ21 (0.1mm-0.2mm) were implanted within the abdominal aorta for up to 6 months. Histological, corrosion, and organ analysis was employed to evaluate tissue response, material performance, and elemental trafficking from LZ21 wires in adult vs. neonate rats. This work provides insight into the performance of LZ21 for pediatric vascular applications. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Magnesium, Characterization |