About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
Alkali-Heat Treated Titanium Loaded with Curcumin for Bone Tissue Engineering; Release Kinetics and In Vitro Biological Properties |
| Author(s) |
Andrew Cedillo, Sahar Vahabzadeh |
| On-Site Speaker (Planned) |
Andrew Cedillo |
| Abstract Scope |
Titanium and its alloys have been widely used for bone and dental tissue engineering applications. However, limited tissue integration and inflammation are the major concerns that can result in implant failure. In this work, we have used alkali-heat treatment to enhance the surface roughness of the Ti, followed by incorporation of curcumin at different amounts, alone or in combination with polyethylene glycol to improve the biological responses. Our results show that release of curcumin highly depends on the loaded amount (50-300 µg) and presence of the polymer either as mixture or coating. Release of curcumin, as a hydrophobic biomolecule is modified in the presence of hydrophilic polyethylene glycol which can help with sustained release of the drug. Incorporation of the curcumin does not have any adverse effect on attachment and proliferation of osteoblast cells up to 7 days of culture, and can be used for hard tissue engineering applications. |