About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Decoupling Bulk and Surface Properties of Functionalized Solvent-Cast 3D Printed Scaffolds |
| Author(s) |
Matthew T. O'Connell, Diana E. Hammerstone, Andrew Kitson, Santiago Lazarte, Brandon A. Krick, Lesley W. Chow |
| On-Site Speaker (Planned) |
Matthew T. O'Connell |
| Abstract Scope |
Cell-material interactions are critical for engineering functional tissue replacements. However, it is difficult to decouple material properties to fine-tune these interactions independently and synergistically. Our lab developed a novel solvent-cast 3D printing platform using peptide-polymer conjugates to fabricate peptide-functionalized scaffolds without affecting physical properties. Building on this platform, we synthesized a new class of end-functionalized polymer conjugates to independently tune surface and bulk mechanical properties. The goal of this work is to demonstrate that we can modify surface properties by printing with end-functionalized conjugates without impacting bulk scaffold properties. Inks containing poly(caprolactone)-bromoisobutryl bromide (PCL-BiBB) conjugates and unmodified PCL were 3D printed into scaffolds functionalized with a polymerization initiator. Oligo(ethylene glycol) methyl ether methacrylate bottlebrushes were polymerized from the scaffold to create a soft, hydrophilic surface while maintaining bulk scaffold mechanical properties. Constructs with varying amounts of PCL-BiBB were fabricated to characterize architecture and mechanical properties. |