About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Early Cell Response to Graphene and Hydroxyapatite-Based Coatings on Ti-6Al-4V for Dental Implant Applications |
| Author(s) |
Sarah Akua Osafo, Tabiri Asumadu, Desmond Klenam, Precious Etinosa, David Obayemi, Benjamin Agyei-Tuffour, Winston Oluwole Soboyejo |
| On-Site Speaker (Planned) |
Sarah Akua Osafo |
| Abstract Scope |
Titanium-based implants are widely used in dentistry and orthopaedics, yet limited early-stage osseointegration often compromises long-term performance. This study explores surface modification of Ti-6Al-4V using graphene, hydroxyapatite (HA), and graphene–HA (G–HA) composite coatings, applied via a novel, low-cost pack cementation method. An annealed Ti-6Al-4V sample was used as control. Surface characterization by Raman spectroscopy, SEM, and EDS confirmed distinct morphological and chemical features across the coatings. Human fetal osteoblast (hFOB) cells were cultured to assess early cell–surface interactions. While graphene and HA coatings improved cell attachment and spreading compared to the control, the G–HA coating demonstrated markedly enhanced cellular response, characterized by pronounced filopodia anchorage and substrate integration. This superior performance is attributed to the combined effects of nanoscale roughness and bioactive chemistry. These findings underscore the potential of G–HA composite coatings to accelerate early cellular activity and support rapid osseointegration in titanium-based dental implants. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Titanium, Surface Modification and Coatings, Biomaterials |