| Abstract Scope |
Engineering physiologically realistic microphysiological systems requires simultaneous advances in fabrication precision, structural scalability, and biological complexity. I will present recent work from my group that collectively address these challenges across complementary fronts. Poudel et al. introduce artificial capillaries-on-a-chip with reproducible, user-defined lumen geometries and in situ editability, overcoming the stochasticity of self-assembled vascular models. Kunwar et al. present a multimodal Digital Light Projection-two-photon hybrid printing platform capable of embedding microscale perfusable networks within centimeter-scale hydrogel constructs, bridging fabrication scale and resolution. Merife et al. translate these advances into a bone-specific context with the BMU-chip, enabling longitudinal study of osteocyte-osteoblast-osteoclast interactions under cyclic mechanical loading. Geffert et al. extend scalability further via modular assembly of cell-seeded, perfusable hydrogel units, enabling clinically relevant tissue volumes without specialized equipment. Together, these works establish an integrated toolkit for building reproducible advanced models for organ-on-chips and tissue engineering applications. |