| Abstract Scope |
Biologically active molecules including growth factors, cytokines, and mRNAs hold significant promise due to their critical roles in tissue repair processes. Therefore, extensive efforts have been made to use them as therapeutic biologics in the clinic. Controlled delivery is crucial for their safe and effective clinical use. In this presentation, I will discuss a controlled delivery system for various biologics, utilizing biomimetic mineral coatings to bind, stabilize, and release biomolecules. We developed mineral coatings that mimic morphological and compositional characteristics of bone and teeth. These mineral coatings were applied to a range of clinically relevant biomaterials, including injectable microparticles, cell scaffolds, surgical devices, and medical implants. Furthermore, we demonstrated in vitro and in vivo that mineral coatings enabled sustained biological effects of proteins, either delivered or overexpressed via gene delivery, by binding with high affinity, stabilizing, and releasing them in a controlled manner. |