About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Anti-Calcification Property of Sulfur Functional Group Using Low Temperature Plasma on Polymeric Scaffolds |
| Author(s) |
John P Bradford, Chandrima P Karthik, Renjith R. Pillai, Sarah P Slavik, Vinoy Thomas |
| On-Site Speaker (Planned) |
Vinoy Thomas |
| Abstract Scope |
Synthetic polymers used as bone-implant biomaterials and bone-scaffolds often suffer limited surface properties for proper bio-mineralization. As a result, they can underperform with respect to biointegration. Low temperature plasma (LTP) has been widely used for surface modification for improving the bio-interface of implant/scaffold materials. In this study LTP using organic plasma precursors (OPP) were explored for biomineralization in vitro to modify the surface of 3D printed poly(lactic acid) (PLA) and poly (ethyl ether ketone) (PEEK) under biomimetic in vitro conditions. Spectral and microscopic methods were employed to image the mineralization products on the surfaces of the scaffolds. Further, a fluorescent assay of surface extracts identified calcium containing mineral deposits at higher levels for plasma-treated scaffolds versus untreated controls. In vitro cellular level studies also indicated biomineralization. Taken together, these results suggest the futuristic potential of OPP-surface modification method for engineering better bio-interfaces for bone implants/scaffolds. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Surface Modification and Coatings |