About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biomedical Materials and Devices: From Laboratory to Market
|
| Presentation Title |
Model-Guided Manufacturing of Bioabsorbable Magnesium Coronary Stents: Linking Laser-Cut Quality to Device Performance |
| Author(s) |
João Cruz, Diego Blunda, Simon Schmidt, Kiarash Mashoufi, Benedikt Bornschlegel, Simon Pöstges, Christian Rüdiger Hinke, Constantin Leon Häfner, Alexander Kopp |
| On-Site Speaker (Planned) |
João Cruz |
| Abstract Scope |
Most laser-cutting optimization studies use flat sheets or simplified geometries, leaving unclear whether laser-cut quality affects performance in complex stents. A straight-cut model was therefore translated to WE43MEO stents using its optimum and seven conditions spanning the response space. Taper angle, recast-affected width, and surface roughness transferred significantly from straight-cut to stents, whereas burr height did not. High-taper conditions showed manufacturing and deployment failures. Radial strength differed significantly among deployable stents (n = 5; Welch ANOVA, p = 0.0015). The optimized condition achieved the highest radial strength, 1.552 ± 0.040 N/mm, compared with 1.425 ± 0.022 N/mm for the lowest-performing condition, while stent recast-affected width explained 82% of radial-strength variation (p = 0.013). After 24 h immersion, most conditions retained 29-33% of initial strength and differences were no longer significant. These findings validate model-guided process development and show that laser-cut quality impacts initial stent function, although degradation reduces processing-dependent differences. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Magnesium, Biomaterials, Process Technology |