About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
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3D Printing of Scaffolds and Porous Materials
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| Presentation Title |
functionalized nanoparticles enhanced PLA for Bone Tissue Engineering |
| Author(s) |
Gargi Shankar Nayak, Amanda Streim, Sergio Manuel Jacinto Hein, Nadine Wiesmann, Ulrike Ritz, Jürgen Brieger |
| On-Site Speaker (Planned) |
Gargi Shankar Nayak |
| Abstract Scope |
The development of suitable bone implants to support bone regeneration remains a major challenge in modern medicine. In such regards, Polylactic acid (PLA) is a promising candidate due to its biocompatibility and biodegradability; however, its poor cellular adhesion and limited osteoconductivity restrict its application. These limitations can be addressed through the incorporation of functionalized Zinc oxide nanoparticles (ZnO NPs) as fillers. ZnO NPs have been surface-functionalized using 3-aminopropyltriethoxysilane (APTES), glycidoxypropyltrimethoxysilane (GPTMS) and via Polyethylene Glycol (PEG). The functionalization strategies have been characterized to evaluate their suitability for biodegradable implant applications. The functionalized ZnO NPs were further incorporated into polylactic acid (PLA) to fabricate a novel filament for fused filament fabrication (FFF) based 3D printing. The biocompatibility of all the 3D printed scaffolds were evaluated via cytotoxicity analysis. Furthermore, their mechanical properties were investigated via uniaxial tensile tests.The functionalized ZnO NPs-PLA scaffolds enhanced the biological and mechanical properties of the PLA. |
| Proceedings Inclusion? |
Planned: None Selected |
| Keywords |
Biomaterials, Polymers, Additive Manufacturing |