About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
|
| Presentation Title |
Biomaterial-induced Activation of the Blood Coagulation Cascade |
| Author(s) |
Christopher Siedlecki, Lichong Xu |
| On-Site Speaker (Planned) |
Christopher Siedlecki |
| Abstract Scope |
The blood coagulation cascade is a complex series of enzymatic reactions leading to the formation of a crosslinked fibrin mesh that is capable of trapping and activating blood platelets, leading to the formation of a thrombus. The intrinsic pathway of this system is activated by contact of the zymogen human Factor XII (also known as Hageman Factor) with a foreign surface such as an implanted biomaterial. It was long believed that the cascade was initiated by FXII contact with anionic surfaces, but more recent studies have shown that a multitude of different surfaces can activate the cascade. In this presentation, we will discuss the relationships between materials bearing a wide variety of surface properties and the subsequent activation of FXII, as well as how surface-activated FXII affects other pathways that lead to propagation of activation, amplification of activated FXII, and even self-inhibition of coagulation. |