About this Abstract |
| Meeting |
2027 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Vascular Biocompatibility and Degradation Performance of Cu-Immobilized Polydopamine-Coated Zinc Implants in Rat Arteries |
| Author(s) |
Md Tanvir Hossain, Jeremy Goldman, H.R. Bakhsheshi-Rad, Bashir Ahamed, Jaroslaw W. Drelich |
| On-Site Speaker (Planned) |
Md Tanvir Hossain |
| Abstract Scope |
Surface functionalization of biodegradable zinc (Zn) implants offers a promising strategy to regulate degradation and improve vascular tissue compatibility. In this study, polydopamine-Cu (PDA-Cu) functionalized coatings were developed on high-purity Zn wires and evaluated using surface characterization, electrochemical testing, and a 4-month rat arterial implantation study. SEM-EDS analysis revealed a relatively uniform PDA-Cu-containing surface with broadly distributed Cu and an average Cu loading of approximately 2-3 wt.%. Electrochemical impedance spectroscopy after 4 h of immersion in Hank’s Balanced Salt Solution demonstrated improved interfacial corrosion resistance following PDA-Cu functionalization. The low-frequency impedance at approximately 0.1 Hz increased from ~106 Ω·cm² for bare Zn to ~145 Ω·cm² for PDA-Cu, representing an ~37% increase. After 4 months of implantation, H&E-stained arterial sections revealed a thinner and more uniformly organized peri-implant tissue response around PDA-Cu -coated Zn, whereas bare Zn exhibited greater neointimal thickening, corrosion-associated deposits, and localized tissue disruption. Quantitative histomorphometric analysis showed that the wire-to-lumen thickness decreased from approximately 70-110 μm for bare Zn to 55-80 μm for PDA-Cu, corresponding to an ~28% reduction. Overall, PDA-Cu functionalization improved the initial electrochemical corrosion resistance of Zn and reduced neointimal tissue formation while promoting a more favorable vascular tissue response. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Surface Modification and Coatings, Polymers |