About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Quantifying Bacterial Interactions at Bio-Nano Interfaces to Engineer Mechanobactericidal Surfaces |
| Author(s) |
Jaqueline Rojas Robles, Jeremiah Abiade |
| On-Site Speaker (Planned) |
Jaqueline Rojas Robles |
| Abstract Scope |
Mechanobactericidal surfaces mimic naturally occurring nanostructures by killing bacteria through mechanical rupture rather than chemical action, offering a promising alternative to traditional biocides. Although these
surfaces have gained widespread interest for their antimicrobial potential,
key gaps remain in understanding how nanoscale design parameters translate to bacterial rupture and loss of viability. In this presentation, we describe the use of atomic force microscopy (AFM) to probe the bio-nano interface between bacteria and engineered nanostructured substrates. By quantifying rupture forces and correlating them with topographical and morphological changes, we assess bacterial responses to mechanical loading. Complementary
antimicrobial assays are used to validate physical damage and viability loss. Together,these measurements provide quantitative guidelines for designing and testing effective mechanobactericidal interfaces. Our results contribute to a
growing framework for rational antimicrobial surface engineering and offer insight into how local mechanical interactions can be tuned to control bacterial fate. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Characterization |