About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
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| Symposium
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Structure-Property Relationships in Molecular Crystal Deformation
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| Presentation Title |
Understanding the Correlation Between Mechanical Properties, Crystal Structure and Tabletability of Pharmaceutical Cocrystals |
| Author(s) |
Sushmita Majumder, Vikram Chandrashekhar Joshi, Changquan Calvin Sun, Nathan A. Mara |
| On-Site Speaker (Planned) |
Sushmita Majumder |
| Abstract Scope |
This study investigates the relationship between crystal structure and nano mechanical properties of pharmaceutical cocrystals. Two cocrystals - carbamazepine-succinic acid and carbamazepine-glutaric acid, were used as model compounds. Nanoindentation measurements were performed on specific crystal faces to determine their hardness, elastic modulus, fracture toughness, and brittleness index values. The results reveal a qualitative correlation between crystal packing, intermolecular interactions, and mechanical behavior. Between the two faces of the cocrystals studied, the one exhibiting stronger three-dimensional hydrogen bonding networks demonstrated higher hardness and elastic modulus values. Further, the cocrystals with a lower brittleness index exhibited improved tabletability and reduced tendency for capping during tableting. Such structure-property insight enables rational design of cocrystals with tailored mechanical properties and enhanced tabletability. It also underscores the potential of nanoindentation as a powerful technique for guiding the rational design of pharmaceutical cocrystals with optimal mechanical properties for tablet formulation. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Characterization, Mechanical Properties, Other |