| Abstract Scope |
Adaptability is crucial for survival in changing environments. I will discuss our research on synthetic self-adaptive biomaterials that alter their mechanical properties based on loading conditions, inspired by bone. We developed a composite material where mineral deposition is triggered by mechanical load on piezoelectric matrices, allowing the material to self-adapt. For example, the mineralization rate can be controlled by varying loading conditions, resulting in a 30-180% increase in material modulus with cyclic loading. We also explore modulating modulus distribution within scaffolds through spatial and temporal control of loading. These findings can help design materials for dynamic mechanical environments, with applications in tissue engineering, reducing stress shielding, accelerating healing, and extending implant lifetimes.
References
[1] Orrego et al., Advanced Materials, 2020, 32: 1906970.
[2] Sun et al., Science Advances, 2025, 11: eadt3979.
[3] Kitchen et al., Nano Research, 2024, 17:633-648. |