| Abstract Scope |
Bioelectronic systems with soft mechanics, stable biocompatibility, and high-performance electronic recording and stimulation interfaces to internal organs offer paradigm-shifting potentials for advancing biomedical implants. Yet, challenges remain in developing biocompatible materials with practical scalability for constructing bioelectronic systems that leverage performance and interfacial attributes to not only functionally approach those of conventional wafer-based technologies but also biologically compatible for long-term in-body operation. Here, we present the orbit symmetry breaking in MXene, a low-cost scalable, flexible, and conductive two-dimensional (2D) material, to entitle the optimized interfacial impedance and Schottky-induced piezoelectric effects. Demonstrated applications include an epicardial patch based on orbit-symmetry-broken MXene featuring high-quality signal transmission and spatiotemporally resolved physiological recordings and stimulations across large areas. The resulting 2D bioelectronics validates applications ranging from microelectrode arrays, gait analysis, and active transistor matrix, which enables high-fidelity biosensing and reconfigurable logic gates. |