About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
A Coordination-Crosslinked Degradable Elastomer |
| Author(s) |
Cole Robert Latvis, Nolan Shan, Katelyn Ge, Amanda Wang, Alan Wells, Hanshuang Shao, Simon Van Herck, Anthony D'Amato, Yadong Wang |
| On-Site Speaker (Planned) |
Cole Robert Latvis |
| Abstract Scope |
Coordination crosslinking between low levels of transition metal ions and biocompatible ligands represents a unique approach for achieving elasticity and robustness in polymeric biomaterials. Here we present a novel copolymer elastomer bearing imidazole ring pendant groups. When exposed to Cu(II) ions at room temperature, coordination bonds are formed yielding tough, but elastic properties. By varying the density of the imidazole rings along the length of the polymer, the exact mechanics, as well as the rate of degradation, can be fine-tuned to desired specifications for various applications. The material also exhibits excellent biocompatibility as assessed by a subcutaneous implantation murine model. Our material offers an exciting method of achieving robust degradable elastomers with controllable properties and has great potential for applications in tissue engineering as a degradable scaffold. |