About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Reconstructing the Fibrous Interfaces of the Intervertebral Disc to Enhance Mechanical Resilience |
| Author(s) |
Haim Salim Mordechai, Javad Tavakoli, Sarit Sivan, Mirit Sharabi |
| On-Site Speaker (Planned) |
Haim Salim Mordechai |
| Abstract Scope |
The mechanical integrity of the intervertebral disc (IVD) relies heavily on its internal fiber networks, particularly the radial and interlamellar structures, which remain poorly understood. We developed a biomimetic approach using silk-based sutures to recreate these native fiber architectures within annulus fibrosus–nucleus pulposus biomimetic constructs. Mechanical testing showed that suture-based radial fibers significantly enhanced shear resistance, minimized delamination, and improved overall cohesion compared to adhesive methods. Finite element analysis further demonstrated that these fibers effectively distributed stresses across the AF–NP interface, reducing local mechanical failure. By replicating native fiber function, the constructs better maintain pressure and load transfer under physiological conditions. These results highlight the essential role of radial fibers in IVD mechanics and offer a promising strategy for designing advanced spinal implants. |
| Proceedings Inclusion? |
Planned: |