About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Deciphering the Role of Microstructure in Governing Corrosion and Aluminum Release in Mg-Al Alloys |
| Author(s) |
Sreenivas Raguraman, Mitchell Connon, Camryn Byrum, Rohit Berlia, Veronica Ivanovskaya, Beril Ulugun, Suhas Prameela, Roger Guillory, Timothy Weihs |
| On-Site Speaker (Planned) |
Sreenivas Raguraman |
| Abstract Scope |
Mg–Al alloys are promising for biodegradable implants due to their mechanical properties and controlled degradation. The clinical adoption of Mg–Al-based stents, such as Freesolve, highlights their potential. However, the interplay between aluminum release during degradation, biological interactions, and implant microstructure remains largely unexplored. This study examines two microstructures, solution-treated (ST) and peak-aged (PA), in relation to corrosion and aluminum release. In vitro studies reveal that PA samples show localized pitting, less stable protective layers, and higher total Al in immersion solutions, mainly from particulate fragments. In vivo studies show ST samples release more soluble ionic Al despite lower corrosion, resulting in higher systemic Al and highlighting the complexity of biological responses. Using advanced characterization and in vivo imaging, this work bridges the gap between laboratory and biological systems, providing a framework to optimize microstructures for balancing corrosion resistance and systemic Al exposure in next-generation Mg–Al-based implants. |