About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Deciphering the Role of Microstructure in Governing Corrosion and Aluminum Release in Mg-Al Alloys |
| Author(s) |
Sreenivas Raguraman, Mitchell Connon, Camryn Byrum, Rohit Berlia, Veronica Ivanovskaya, Beril Ulugun, Suhas Prameela, Roger Guillory, Timothy Weihs |
| On-Site Speaker (Planned) |
Sreenivas Raguraman |
| Abstract Scope |
Magnesium alloys with aluminum are promising materials for biodegradable implants due to their mechanical properties and biodegradability. The clinical adoption of Mg-Al-based stents, such as Freesolve, highlights their potential. The interplay between aluminum release during degradation, biological interactions, and implant microstructure remains largely unexplored. This study investigates how two microstructures—solution treated and peak aged—influence corrosion and Al release. In-vitro studies of degradation pathways show that Al-rich precipitates in peak-aged samples promote localized pitting, destabilize passive layers, and increase Al release. Conversely, in-vivo studies show higher systemic Al release in whole blood from solution-treated samples compared to peak-aged samples, demonstrating the complexities of the biological response and its impact on biodegradable metal implant performance. Using advanced characterization, in-vivo imaging, and histological analysis, this work bridges the gap between laboratory and biological systems, providing a framework to optimize microstructures for balancing corrosion resistance and ion release in next-generation Mg-Al-based implants. |