| Abstract Scope |
Biocompatibility is the primary hurdle in moving implantable medical devices from the lab to the clinic. As bioelectronics become increasingly soft, electrically active, and capable of dissolving safely in the body (bioresorbable), older definitions of biocompatibility—which mostly focused on avoiding cell toxicity and severe swelling—are no longer adequate. These emerging "transient" devices require a multidimensional approach. They must actively manage immune responses, match the body's mechanical and electrical properties, break down predictably, and stay functional for the required timeframe. This presentation examines recent progress in bioresorbable electronics through this updated biocompatibility lens. We highlight how the combination of materials, device design, and degradation mechanisms dictates tissue integration and immune reactions. Additionally, we provide a framework comparing different materials by their immune and degradation profiles, and we critically evaluate current testing standards like ISO 10993. Finally, we offer design principles and outline future research goals. |