About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
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| Symposium
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Biomaterials for 3D Printing of Scaffolds & Porous Materials
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| Presentation Title |
Biomimetic 3D-printed PCEC/collagen composite scaffold as the support of osteogenesis for large bone defect repair |
| Author(s) |
Yuyao Liu, Marko Dobricic, Claudio Intini, Fergal J. O'Brien, Mónica Echeverry-Rendón, Javier Llorca |
| On-Site Speaker (Planned) |
Javier Llorca |
| Abstract Scope |
The repair of large traumatic bone defects remains a huge challenge in orthopedic clinics due to the complicated environment of bone healing. In this study, a novel biomimetic composite scaffold with hierarchical porosity was fabricated by incorporating a bioactive collagen type I and nano-hydroxyapatite (CI-nHA) matrix to a 3D-printed porous poly(ε-caprolactone) - polyethylene glycol 20k - poly(ε-caprolactone) (PCL-PEG20k-PCL, PCE20kC) triblock copolymer framework. The composite scaffold showed similar mechanical properties to native cancellous bone. In vitro biological experiments demonstrated that it sustained osteogenesis and mineralization of pre-osteoblast cells, as well as supported luminal formation and angiogenesis by endothelial cells. Furthermore, when subjected to mechanical stimulation in a bioreactor with simulated physiological mechanical condition, the composite scaffold supported osteoblast viability and enhanced early mineralization. Therefore, this novel biomimetic composite scaffold with adequate mechanical properties, degradation rate, osteogenesis and angiogenesis, shows great promise as a new treatment for large bone defect repair. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Additive Manufacturing |