About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
2026 Technical Division Student Poster Contest
|
| Presentation Title |
SPG-10: Developing a Multifunctional, Shear-Thinning Nanoclay-Based Embolic Platform for Precise Minimally Invasive Procedures |
| Author(s) |
Keren Zhao, Peng Chen, George Varghese PJ, Jingjie Hu |
| On-Site Speaker (Planned) |
Keren Zhao |
| Abstract Scope |
Embolization is a minimally invasive procedure widely used to occlude blood supply and deliver drugs to targeted tissues. Recently, shear-thinning embolic agents have emerged as promising materials due to their favorable properties, including injectability, mechanical robustness, biocompatibility, and ability to conform to a wide diameter range of vessels. Despite advantages, their clinical translation remains limited due to a short history.
In this poster, we present the development of alginate-reinforced nanoclay (NA) shear-thinning embolic platform. The NA system injectable due to the shear-thinning behavior, while maintaining mechanical strength and biocompatibility after deployment. This platform allows incorporation of functional agents, including iohexol for X-ray visibility and indocyanine green (ICG) for fluorescence imaging. Moreover, therapeutic agents can be incorporated to provide additional functions, such as ICG for photothermal ablation or genipin for anti-inflammatory effects. Overall, the NA system is a versatile platform with strong multifunction potential for image-guided and therapeutically enhanced vascular embolization. |
| Proceedings Inclusion? |
Undecided |
| Keywords |
Biomaterials, Polymers, Ceramics |