About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Magnetite nanoparticles-polydimethylsiloxane nanocomposite interactions with lasers for the hyperthermia treatments of localized triple-negative breast cancer: A comparison of magnetite nanospheres and nanorods |
| Author(s) |
Chukwudi Canice Ezeala, John David Obayemi , Wole Soboyejo |
| On-Site Speaker (Planned) |
Chukwudi Canice Ezeala |
| Abstract Scope |
Triple-negative breast cancer is an aggressive form of cancer that is difficult to treat. There is therefore a need for improved methods for the treatment of triple-negative breast cancer. Hyperthermia therapy is a type of cancer treatment that uses heat to destroy cancer cells and shrink tumors. This study looks at how the shape of magnetite nanoparticles in implantable polydimethylsiloxane (PDMS) devices affects the heating of triple-negative breast cancer cells and tissues when lasers hit the nanoparticles. The results show that PDMS devices with rod-shaped magnetite heat up to hyperthermia temperatures (40-44°C) faster than those with round magnetite nanoparticles when tested under the same conditions. Using magnetite nanorods in PDMS nanocomposites heats up faster and is less damaging to nearby healthy cells, making them a beneficial choice for treating difficult triple-negative breast cancer. |