About this Abstract |
| Meeting |
MS&T25: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
4D Bioprinting of Biomimetic Trilayer Scaffolds for Uterine Tissue Regeneration |
| Author(s) |
Shangsi Chen, Liwu Zheng, Min Wang |
| On-Site Speaker (Planned) |
Min Wang |
| Abstract Scope |
The uterus is a vital organ for motherhood and damages and diseases in the uterus are difficult to treat in many cases. Novel tissue engineering strategies are therefore investigated to develop biomimetic scaffolds with specialized living cells and biomolecules for regenerating the uterus. As has been seen widely, 4D printing and bioprinting are powerful in fabricating scaffolds and cell-scaffold constructs for body tissue regeneration. In this study, novel 3D scaffolds with a biomimetic and hierarchical structure, high elasticity and controlled biomolecule delivery ability were made via 4D printing, electrospinning and bioprinting, mimicking the anatomical structure and functions of human uterus. The new trilayer scaffolds consisted of poly(L-lactide-co-trimethylene carbonate)/thermoplastic polyurethane polymer blend scaffold layer (for in situ shape-morphing), estradiol-containing poly(lactic-co-glycolic acid)/gelatin fiber layer, and bone-marrow derived mesenchymal stem cell-containing gelatin methacryloyl/gelatin hydrogel layer. These scaffolds were able to change from planar to curved shapes at 37C for fitting the uterus curvatures. |