About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Genipin-Crosslinked Shear-Thinning Nanoclay/Iohexol/Alginate Gel for Image-Guided Embolization |
| Author(s) |
Keren Zhao, Peng Chen, George Varghese , Jingjie Hu |
| On-Site Speaker (Planned) |
Keren Zhao |
| Abstract Scope |
Embolization is a minimally invasive technique used to block blood supply and deliver drugs to diseased tissues such as tumors and vascular malformations. Shear-thinning embolic agents are valued for their injectability and shear-responsive behavior. However, clinical translation remains limited, with key aspects such as microcatheter injectability, structural performance, and multifunctionality underexplored.
We present a systematic study of a shear-thinning embolic agent composed of Laponite nanoclay, Iohexol, alginate, and Genipin (NIAG). In this system, nanoclay forms a “house-of-cards” microstructure, with alginate reinforcing the matrix. Iohexol provides strong radiopacity under fluoroscopy, comparable to commercial Omnipaque. Genipin acts as a crosslinker, enhancing gel strength and promoting a stable interface with blood.
NIAG is designed for microcatheter delivery and exhibits suitable rheological properties under physiological conditions. In vitro evaluations confirmed its radiopacity, biocompatibility, and anti-inflammatory performance. These findings highlight NIAG as a promising multifunctional embolic agent for safe and effective vascular embolization. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Ceramics, Mechanical Properties |