| Abstract Scope |
Targeted delivery of therapeutics in the gastrointestinal tract requires materials capable of controlled navigation and localized release. We developed shape-programmable, microporous magnetic soft elastomers enabling wireless locomotion and precise on-demand liquid cargo delivery. By programming spatial magnetization profiles, these bioinspired soft materials achieve complex shape-morphing under external magnetic fields. We introduce an interconnected microporous internal structure that allows loading of aqueous payloads without compromising magnetic programmability. To protect the payload during transport, the release interface is sealed with a microcrystalline wax layer. By applying specific magnetic fields, the soft material undergoes severe mechanical bending deformation, which ruptures the wax seal to enable directional and localized release of therapeutic agents. This presentation discusses the design, fabrication, and wireless actuation of these materials, highlighting their potential as minimally invasive platforms for treating gastrointestinal diseases. |