| Abstract Scope |
Metal nanoparticles are important for several applications, including biomedicine, catalysis, energy generation/storage, cosmetics, biosensors, and surface coatings. However, challenges persist regarding synthesis duration, nanoparticle shape management, and surface alterations. Complex interactions at the nano-bio interface hinder the development of selective biocidal nanomaterials as an antibiotic alternatives. Futhermore, in FRET-based biosensing, nanoparticles with high specificity are essential for avoiding unintended interactions. Therefore, Enhancing nanoparticle selectivity for specific analytes is vital for advancing FRET-based biosensing. Polyethyleneimine-stabilized gold nanoparticles exhibit exceptional control over nanoscale geometry, enhanced stability under ambient conditions, and selective binding with specific antibiotic molecules. This study used fluorescence spectrophotometry to examine the interaction dynamics of polyethyleneimine-functionalized silver nanoparticles at the C. albicans cell bio-interface; vancomycin conjugation was observed on gold nanoparticles for broad-spectrum antimicrobial applications. Moreover, PEI-stabilized gold nanoparticles serve as excellent energy acceptors for the FRET-based sensing of glutathione, polymyxin B, and other environmental contaminants. |