About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials and Implants
|
| Presentation Title |
Biomimetic Surface Modification of Titanium Implants to Mitigate Antibacterial Efficacy and Enhance Cell Functionality |
| Author(s) |
Ketul C. Popat |
| On-Site Speaker (Planned) |
Ketul C. Popat |
| Abstract Scope |
Implanted medical devices often face the challenge of infections, which can compromise their
successful integration. To address this issue, we have covalently grafted a tannin-based antimicrobial biopolymer tanfoc (TAN) and a self-assembling dipeptide N-fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) onto the titania nanotube arrays (TiNTs) surface to enhance antibacterial properties. Due to its polyphenolic/ionic structural configuration, tanfloc possesses unique properties that enable it to interact with/disrupt bacterial cell walls and membranes. Fmoc-FF peptides, in conjugation with TiNT, can inhibit biofilm formation, eradicate pre-existing biofilm, and kill bacteria. A synergistic effect can be achieved by combining the topographical features of TiNTs with the inherent antibacterial characteristics of tanfloc and Fmoc-FF. The successful attachment of tanfloc and Fmoc-FF can also enhance stem cell functionality. The results suggest that the covalent conjugation onto TiNTs is a promising approach to improve the infection resistance of titanium-based medical implants. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Surface Modification and Coatings |