About this Abstract |
| Meeting |
2026 TMS Annual Meeting & Exhibition
|
| Symposium
|
Late News Poster Session
|
| Presentation Title |
J-19: Multi-Level In Vitro Systems for Evaluating Magnesium Materials in Atherosclerotic Environments |
| Author(s) |
Carolyn Czerniak, Elizabeth Wintersheimer, Roger Guillory |
| On-Site Speaker (Planned) |
Carolyn Czerniak |
| Abstract Scope |
While it is known that magnesium (Mg) alloys can be sensitive to biological factors, the impact of the atherosclerotic environment on vascular Mg devices has not been studied. We have shown that clinically relevant Mg-Y-Nd alloys experience corrosion heterogeneity in hyperlipidemic apolipoprotein E knock-out (ApoE-/-) mice, and that supplementing immersion medium with human low- and high-density lipoproteins increased in vitro corrosion rate in a dose- and species-dependent manner. In this project, we developed in vitro systems that recapitulate aspects of the atherosclerotic environment to evaluate clinically relevant Mg alloys. We utilized hydrogels to create a novel in vitro atherosclerotic plaque model with similar lipid content as human plaques and evaluated device corrosion under flow rates consistent with human coronary arterial flow in the presence of serologic levels of lipoproteins. Combined, these efforts provide a greater understanding of Mg device corrosion behavior and overall performance in the highly heterogeneous atherosclerotic environment. |
| Proceedings Inclusion? |
Undecided |
| Keywords |
Magnesium, Biomaterials, |